medical marijuana for psoriasis

Medical marijuana for psoriasis

Psoriasis is a chronic inflammatory skin and possibly an autoimmune disease that causes scaly lesions, redness, swelling and skin irritation. It is not contagious, but it can be hereditary affecting more men than women aged 15-35 years. What happens during this illness is that the cell renewal cycle is much shorter (the rate of normal renewal of dead cells is around one month) may be a few days or up to two weeks, causing excessive accumulation of dead cells on the surface of the skin, creating lesions characteristic of the disease.

There are 5 different types of psoriasis, erythrodermic (intense reddening in a large area of the body), Guttata (small pink ares with red spots) whose appearance is linked to streptococcal infections, inverse psoriasis (armpits and groin irritation), psoriasis plate (thick patches covered with silvery white scales) this is the most common and pustular psoriasis (blisters pustules surrounded by red skin).

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Benefits against Psoriasis


The analgesic effect of cannabinoids is one of the best characterized effects for people suffering from psoriasis. Flaking and itching decreases in addition to moisturizing the affected area.

The use of Cannabinoids for Psoriasis

Mast cells are cells that regulate inflammatory processes by releasing interleukins, histamines, proteases, TNF, and various others. Due to this, there have been studies to evaulate if the cannabinoid receptor CB1R could act as a mediator and inhibit the inflammation and toxicity within the cells in individuals with proriasis. Studies have shown that the CB1R is a strong agonist in the mast cell proliferation and topical application of it works to suppress mast cell recruitment into the skin, thus reducing the level of histamine in the blood. The use of cannabinoid CB1R is very beneficial in relieving symptoms caused by inflammatory skin diseases such as, but not limitied to psoriasis. [1]

CBD is a proper treatment for prosiasis due to its potent anti-inflammatory properties and the ability for patients to use the the CBD receptors on the skin in the form of creams or oils. Additionally, cannabinoids play an important role in the regulation of keratinocyte hyperproliferation leather (characteristic present in psoriasis).[2]

Bibliography for Psoriasis and Cannabinoids

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Psoriasis is a chronic inflammatory and possibly autoimmune skin disease that can be helped by the cannabinoids present in medical marijuana.

Is Cannabis an Effective Treatment for Psoriasis?

Cannabis, or marijuana, is now being used to treat pain and conditions such as Crohn’s disease, glaucoma, and nausea from chemotherapy. The evidence is mounting that cannabis may also be effective in treating everything from multiple sclerosis and Parkinson’s disease to schizophrenia and post-traumatic stress disorder. But can cannabis be used to treat psoriasis?

Psoriasis is a chronic autoimmune disorder that causes the rapid build-up of skin cells. The new skin cells are produced so quickly that they reach the surface of the skin before they’re mature. This immature buildup on the surface of the skin forms itchy, raised patches of silvery scales. Parts of your body may also become inflamed, and you may have redness, swelling, and discomfort.

About 15 percent of people who have psoriasis will develop psoriatic arthritis. This condition causes painful swelling and stiffness of the joints. If left untreated, it can also lead to permanent joint damage.

Pain, fatigue, and sleeplessness often occur with psoriasis. Psoriasis can also take a profound toll on your mental health.

The National Psoriasis Foundation notes that people with psoriasis are at an increased risk for depression, anxiety, and suicide. A 2010 study published in the Archives of Dermatology found that people living with psoriasis have a 39 percent higher risk of being diagnosed with depression than those without the disease. They also have a 31 percent higher risk of being diagnosed with anxiety.

Psoriasis isn’t curable and can be difficult to control. Although there are a variety of medications and light therapies for treating the disease, some have serious side effects and others lose their effectiveness when your body builds up a resistance to them.

Given the physical and emotional burden of psoriasis, new treatment options are needed. Cannabis is one of the treatment possibilities being explored. Research into the effectiveness of cannabis addresses different aspects of the disease.

Slowing cell growth

Some studies suggest cannabis may be useful in slowing the rapid growth of keratinocytes. These are the immature skin cells found in people with psoriasis. One study suggests that cannabinoids and their receptors may help control and limit the production of immature skin cells. Researchers add that cannabis may be useful in treating several conditions involving keratinocytes, including psoriasis and wound healing.

Controlling pain

Many people use marijuana to control pain. Cannabis may be more effective than opioids in controlling acute and neuropathic pain. It may also be useful in reducing chronic pain, according to an article in Current Rheumatology . An article published in the Journal of the American Medical Association also suggests that marijuana may be effective in treating pain.

Regulating the immune system

Although more research is needed, some studies indicate that cannabis reduces the severity of inflammation associated with some conditions, including autoimmune disorders like psoriasis. An article published in the journal Pharmacology indicates that cannabis can suppress the immune system.

Most research has focused on forms of cannabis that are taken by mouth. Cannabis is also available as oil. Some people use this oil topically to treat psoriasis, claiming that it controls the speed of skin cell production and reduces inflammation. More research is needed to support these claims.

Treatment of stress

Psoriasis and stress go hand in hand, and THC has been shown to relieve stress. However, researchers note that while low doses of THC can produce stress-relieving effects, higher doses may actually have a negative effect on mood.

Cannabinoids hold the key

Cannabinoids are active chemicals found in marijuana plants. Your body makes cannabinoids, too. These chemical messengers are called “endocannabinoids.” They play a role in some functions in your body, including:

  • inflammation
  • immunity
  • appetite
  • the pressure in your eye
  • mood
  • reproduction

Cannabis holds promise for treating the symptoms of psoriasis. It’s well-established that cannabis can be useful in controlling pain. More research is needed to determine if it’s safe and effective, though. The manner in which cannabis is used also needs more testing. Cannabis can be used in a variety of forms, including:

  • pills
  • inhalants
  • vaporizers
  • tinctures

Cannabis hasn’t been better studied because it’s a Schedule I substance under the United States Controlled Substances Act. Schedule I substances are considered to have a high potential for abuse, have no accepted medical use, and may not be safe for use under medical supervision.

These restrictions have posed a significant obstacle to cannabis research. Still, state laws allowing the use of medical marijuana have encouraged more research and efforts to deregulate the drug.

Cannabis is being increasingly used to treat a number of conditions and their symptoms. But how does it shape up as a potential treatment for psoriasis? ]]>